Overview
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.2
USERS' SCORE
Good
Based on 6 Reviews
8.2
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
Top Medical Research Studies
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Read More
8
We investigated how a mixture of vitamins B6, B9, and B12 (VITB) affects heart health in mice with Marfan syndrome. Over 20 weeks, VITB treatment led to reduced heart rate and smaller aorta size in these mice. Notably, VITB helped restore important gene expressions and improved TGF-β signaling, which is crucial for collagen maturation in the aorta. While this study shows promise for VITB in managing heart disease related to Marfan syndrome, further research is needed to confirm its efficacy in humans.
Read More
7
Vitamin B12 may lower inflammation
We examined how vitamin B12 levels relate to heart disease risk by looking at inflammatory markers in 136 individuals at high risk. Our findings revealed that those with higher vitamin B12 had lower levels of IL-6 and CRP, both linked to inflammation.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
Read More
Most Useful Reviews
8
Pain relief
8 people found this helpful
B12 is of excellent quality with quick delivery to the postamat. The capsules are convenient for oral intake. After experiencing incessant back pains around my heart post-coronavirus, I took this on my doctor's recommendation. The taste is pleasant, with high purity ingredients. I've noticed my back pain has ceased, and my energy levels have surged within a week of use. It contains 1,500 mcg of B12.
Read More
9
Health benefits
3 people found this helpful
Vitamin B12 is crucial for good health, boosting energy and preventing heart disease. It significantly enhanced the quality of my hair and nails, especially when combined with vitamin D3. My memory has also improved. Vitamin B12 is vital for overall health.
Read More
7.5
Neurological health
B12 is crucial for concentration and energy, contributing to neurological health, mood stability, metabolism, and combating heart disease. I’m pleased with the results from taking the methylcobalamin form of this vitamin.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.2
- All Researches
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Read More
8
We investigated how cow’s milk intake influences the risk of coronary heart disease (CHD) in postmenopausal women. Analyzing data from the Korea National Health and Nutrition Examination Survey, we included 1,825 women aged 50–64.
Our findings indicated that those consuming cow’s milk more frequently (more than three times a week) had better levels of HDL cholesterol and lower CHD risk factors compared to those who did not consume milk.
This suggests that regular cow’s milk consumption could be beneficial for heart health in this group.
Our findings indicated that those consuming cow’s milk more frequently (more than three times a week) had better levels of HDL cholesterol and lower CHD risk factors compared to those who did not consume milk.
This suggests that regular cow’s milk consumption could be beneficial for heart health in this group.
Read More
8
We investigated how a mixture of vitamins B6, B9, and B12 (VITB) affects heart health in mice with Marfan syndrome. Over 20 weeks, VITB treatment led to reduced heart rate and smaller aorta size in these mice. Notably, VITB helped restore important gene expressions and improved TGF-β signaling, which is crucial for collagen maturation in the aorta. While this study shows promise for VITB in managing heart disease related to Marfan syndrome, further research is needed to confirm its efficacy in humans.
Read More
7
Vitamin B12 may lower inflammation
We examined how vitamin B12 levels relate to heart disease risk by looking at inflammatory markers in 136 individuals at high risk. Our findings revealed that those with higher vitamin B12 had lower levels of IL-6 and CRP, both linked to inflammation.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
Read More
7
B-vitamins reduce mortality risk
We explored how using calcium channel blockers (CCBs) affects survival in patients with suspected stable angina and the potential role of B-vitamin treatment. A study with nearly 4,000 patients found that those who used CCBs without receiving B-vitamins had a higher mortality risk.
Conversely, patients treated with B-vitamins showed no significant increase in mortality rates related to CCB use. This suggests that B-vitamins may offer protective benefits for heart health, particularly for those on CCBs.
Conversely, patients treated with B-vitamins showed no significant increase in mortality rates related to CCB use. This suggests that B-vitamins may offer protective benefits for heart health, particularly for those on CCBs.
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User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
8
Pain relief
8 people found this helpful
B12 is of excellent quality with quick delivery to the postamat. The capsules are convenient for oral intake. After experiencing incessant back pains around my heart post-coronavirus, I took this on my doctor's recommendation. The taste is pleasant, with high purity ingredients. I've noticed my back pain has ceased, and my energy levels have surged within a week of use. It contains 1,500 mcg of B12.
Read More
9
Health benefits
3 people found this helpful
Vitamin B12 is crucial for good health, boosting energy and preventing heart disease. It significantly enhanced the quality of my hair and nails, especially when combined with vitamin D3. My memory has also improved. Vitamin B12 is vital for overall health.
Read More
7.5
Neurological health
B12 is crucial for concentration and energy, contributing to neurological health, mood stability, metabolism, and combating heart disease. I’m pleased with the results from taking the methylcobalamin form of this vitamin.
Read More
7
Prevention advice
8 people found this helpful
I recommend this B12 as I had low levels of it. I took one capsule daily for a week, then one per week for two months. This form of methylcobalamin is easily absorbed and helps boost levels effectively. I suggest this for myself and my parents as many elderly people lack this vitamin, which can lead to dementia and heart disease.
Read More
7.5
Cognitive improvement
1 people found this helpful
This vitamin is essential for maintaining a healthy nervous system and promotes red blood cell production. I found that ensuring adequate B12 helps improve cognitive function and reduce the risk of heart disease while enhancing skin and hair health.
Read More
Frequently Asked Questions
8
Pain relief
8 people found this helpful
B12 is of excellent quality with quick delivery to the postamat. The capsules are convenient for oral intake. After experiencing incessant back pains around my heart post-coronavirus, I took this on my doctor's recommendation. The taste is pleasant, with high purity ingredients. I've noticed my back pain has ceased, and my energy levels have surged within a week of use. It contains 1,500 mcg of B12.
7.5
Cognitive improvement
1 people found this helpful
This vitamin is essential for maintaining a healthy nervous system and promotes red blood cell production. I found that ensuring adequate B12 helps improve cognitive function and reduce the risk of heart disease while enhancing skin and hair health.
7
Prevention advice
8 people found this helpful
I recommend this B12 as I had low levels of it. I took one capsule daily for a week, then one per week for two months. This form of methylcobalamin is easily absorbed and helps boost levels effectively. I suggest this for myself and my parents as many elderly people lack this vitamin, which can lead to dementia and heart disease.
7.5
Neurological health
B12 is crucial for concentration and energy, contributing to neurological health, mood stability, metabolism, and combating heart disease. I’m pleased with the results from taking the methylcobalamin form of this vitamin.
9
Health benefits
3 people found this helpful
Vitamin B12 is crucial for good health, boosting energy and preventing heart disease. It significantly enhanced the quality of my hair and nails, especially when combined with vitamin D3. My memory has also improved. Vitamin B12 is vital for overall health.
7.5
Improved vitality
1 people found this helpful
Vitamin B12 is vital for many bodily functions, including raising blood pressure and normalising cholesterol. It enhances the immune system and can decrease the risk of heart disease. I’m pleased with its effects on my overall well-being.
7
Vitamin B12 may lower inflammation
We examined how vitamin B12 levels relate to heart disease risk by looking at inflammatory markers in 136 individuals at high risk. Our findings revealed that those with higher vitamin B12 had lower levels of IL-6 and CRP, both linked to inflammation.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
5
We explored the relationship between serum levels of vitamin B12 and folate and cardiovascular disease (CVD) mortality in patients with type 2 diabetes. This large study analyzed data from over 8,000 individuals to identify risks associated with different levels of these vitamins.
Our findings showed that both low and high levels of vitamin B12, along with low folate, were linked to a higher chance of dying from heart disease. This suggests a complex role of these vitamins in heart health for those with diabetes.
Our findings showed that both low and high levels of vitamin B12, along with low folate, were linked to a higher chance of dying from heart disease. This suggests a complex role of these vitamins in heart health for those with diabetes.
References
- Chen B, Wang C, Li W. Genetic insights into the effect of trace elements on cardiovascular diseases: multi-omics Mendelian randomization combined with linkage disequilibrium score regression analysis. Front Immunol. 2024;15:1459465. doi:10.3389/fimmu.2024.1459465
- Domínguez-López I, Kovatcheva M, Casas R, Toledo E, Fitó M, et al. Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice. J Sci Food Agric. 2024;104:875. doi:10.1002/jsfa.12976
- Qin Y, Shi Y, Yu Q, Yang S, Wang Y, et al. Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway. Biomed Pharmacother. 2023;163:114761. doi:10.1016/j.biopha.2023.114761
- Dhar I, Svingen GF, Bjørnestad EØ, Ulvik A, Saeed S, et al. B-vitamin Treatment Modifies the Mortality Risk Associated with Calcium Channel Blockers in Patients with Suspected Stable Angina Pectoris: A Prospective Cohort Study. Am J Clin Nutr. 2023;118:77. doi:10.1016/j.ajcnut.2023.04.033
- Ha AW, Kim WK, Kim SH. Cow's Milk Intake and Risk of Coronary Heart Disease in Korean Postmenopausal Women. Nutrients. 2022;14. doi:10.3390/nu14051092
- Liu Y, Geng T, Wan Z, Lu Q, Zhang X, et al. Associations of Serum Folate and Vitamin B12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes. JAMA Netw Open. 2022;5:e2146124. doi:10.1001/jamanetworkopen.2021.46124
- Huang TH, Chang HH, Guo YR, Chang WC, Chen YF. Vitamin B Mitigates Thoracic Aortic Dilation in Marfan Syndrome Mice by Restoring the Canonical TGF-β Pathway. Int J Mol Sci. 2021;22. doi:10.3390/ijms222111737
- Aggarwal P, Sinha SK, Khanra D, Razi M, Nath RK, et al. Hematinic deficiency in patients with heart failure with reduced ejection fraction (HFrEF). Ann Cardiol Angeiol (Paris). 2022;71:153. doi:10.1016/j.ancard.2021.09.014
- Hjalmarsson C, Backelin C, Thoren A, Bergh N, Sloan JL, et al. Severe heart failure in a unique case of cobalamin-C-deficiency resolved with LVAD implantation and subsequent heart transplantation. Mol Genet Metab Rep. 2024;39:101089. doi:10.1016/j.ymgmr.2024.101089
- Mohan A, Kumar R, Kumar V, Yadav M. Homocysteine, Vitamin B12 and Folate Level: Possible Risk Factors in the Progression of Chronic Heart and Kidney Disorders. Curr Cardiol Rev. 2023;19:e090223213539. doi:10.2174/1573403X19666230209111854
